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AniLocus   →  Encyclopedia   →  Animal Models   →  Animal Models

Animal Models

Definition:

Animal models are non-human species used in biomedical research for the investigation of human development and disease.

Outcome:

Animal models include rodents, fish, amphibians, non-human primates, canines, felines, large mammals, insects, birds, and many other animals.

Translational Studies:

Animal models are considered translational because many DNA sequences are shared between different animals and humans. For example, mice and humans share 90% DNA sequence homology while non-human primates share 98% of their DNA sequences with humans.

Our Services:

At AniLocus, the most common animal models are rodents while other species can be used for preclinical in vivo research of multiple therapeutics. Contact us to determine which model is applicable to your in vivo studies.

More Information:

  1. Mukherjee, P., Roy, S., Ghosh, D., & Nandi, S. K. (2022). Role of animal models in biomedical research: a review. Laboratory animal research, 38(1), 18. https://doi.org/10.1186/s42826-022-00128-1.
  2. Williams, S. M., Haines, J. L., & Moore, J. H. (2004). The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?. BioEssays : news and reviews in molecular, cellular and developmental biology, 26(2), 170–179. https://doi.org/10.1002/bies.10401.
  3. Darrell R. Boverhof, Mark P Chamberlain, Clifford R. Elcombe, Frank J. Gonzalez, Robert H. Heflich, Lya G. Hernández, Abigail C. Jacobs, David Jacobson-Kram, Mirjam Luijten, Adriana Maggi, Mugimane G. Manjanatha, Jan van Benthem, B. Bhaskar Gollapudi, Transgenic Animal Models in Toxicology: Historical Perspectives and Future Outlook, Toxicological Sciences, Volume 121, Issue 2, June 2011, Pages 207–233, https://doi.org/10.1093/toxsci/kfr075.
  4. Onaciu, A., Munteanu, R., Munteanu, V. C., Gulei, D., Raduly, L., Feder, R. I., Pirlog, R., Atanasov, A. G., Korban, S. S., Irimie, A., & Berindan-Neagoe, I. (2020). Spontaneous and Induced Animal Models for Cancer Research. Diagnostics (Basel, Switzerland), 10(9), 660. https://doi.org/10.3390/diagnostics10090660.

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