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Definition:
Ovariectomy (OVX) is the surgical removal of the ovaries from the female reproductive tract.
Outcome:
Loss of the ovaries reduces circulating estrogen levels in female animals.
Translational Studies:
The ovariectomy in laboratory research animals simulates lowered circulating estrogen levels seen in aging, hypoestrogenemia, osteoporosis, menopause, and endocrine disorders with reproductive consequences.
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At AniLocus, the ovariectomy model in rodents is used in preclinical in vivo research for metabolism, cardiovascular disease, obesity, oncology, fertility, neurological disorders, and more.
