Safety Pharmacology CRO

Safety Pharmacology CRO

In the realm of pharmaceutical development, the significance of safety pharmacology in vivo animal studies cannot be overstated. These studies play a pivotal role in assessing the impact of new drugs on vital organ systems before they progress to human trials. Anilocus, a growing contract research organization (CRO) and provider of comprehensive safety pharmacology services. We offer a range of specialized studies that adhere to international regulatory guidelines. With a focus on rodent models, we carefully select the most appropriate animal models to ensure accurate and reliable results. By conducting cardiovascular, central nervous system, and respiratory assessments, these studies provide invaluable data to guide the design of clinical trials. This feature about our safety pharmacology CRO services delves into the intricacies of safety pharmacology, shedding light on the different types of studies and how they translate into the context of clinical trials. Contact us for free quote to learn more about our safety pharmacology CRO services.

Safety Pharmacology Services

We understand the importance of in vivo safety pharmacology assessments for evaluating the safety of drug products. Review our categorized list of common assessments by system:

Cardiovascular System Assessments:

  • Blood pressure measurement
  • Electrocardiography (ECG) analysis
  • Evaluation of cardiac contractility
  • Assessment of heart rate variability
  • Evaluation of potential arrhythmias

Central Nervous System Assessments:

  • Measurement of spontaneous locomotor activity
  • Assessment of motor coordination and balance
  • Evaluation of cognitive function and learning ability
  • Observation of sleep patterns and electroencephalography (EEG)
  • Measurement of seizure susceptibility

Respiratory System Assessments:

  • Evaluation of respiratory rate and pattern
  • Assessment of cough reflex and pulmonary function
  • Measurement of bronchial reactivity
  • Observation of respiratory reflexes and responses

Gastrointestinal System Assessments:

  • Assessment of gastrointestinal motility
  • Measurement of gastric and intestinal transit time
  • Evaluation of gastric acid secretion
  • Observation of appetite and food intake
  • Assessment of potential gastrointestinal toxicity

Renal System Assessments:

  • Measurement of urine volume and composition
  • Evaluation of renal blood flow and glomerular filtration rate
  • Assessment of tubular function and electrolyte balance
  • Observation of renal histopathology and markers of renal injury

Hepatic System Assessments:

  • Evaluation of liver function tests (e.g., serum enzymes, bilirubin)
  • Measurement of hepatic drug metabolism and clearance
  • Assessment of hepatic steatosis and fibrosis
  • Observation of hepatic histopathology and markers of liver injury

Endocrine System Assessments:

  • Measurement of hormone levels (e.g., cortisol, insulin, thyroid hormones)
  • Evaluation of glucose homeostasis and insulin sensitivity
  • Assessment of reproductive function and fertility
  • Observation of endocrine-related organ histopathology

Central Nervous System Assessments:

  • Measurement of spontaneous locomotor activity
  • Assessment of motor coordination and balance
  • Evaluation of cognitive function and learning ability
  • Observation of sleep patterns and electroencephalography (EEG)
  • Measurement of seizure susceptibility

Central Nervous System Assessments:

  • Measurement of spontaneous locomotor activity
  • Assessment of motor coordination and balance
  • Evaluation of cognitive function and learning ability
  • Observation of sleep patterns and electroencephalography (EEG)
  • Measurement of seizure susceptibility
Regulatory Compliance

GLP

Study Purpose

Drug Safety

Study Duration

Weeks to Months

Animal Species

Mouse, Rat

Est. Research Budget

$50,000-$1,000,000