Toxicology CRO

Toxicology CRO

We specialize in conducting in vivo toxicology studies, employing state-of-the-art methods to evaluate the potential toxicity and harmful effects of new drugs and biomaterials. Our rigorous biological system-specific experiments, provide vital data for drug development, ensuring the safety and efficacy of pharmaceutical products.

We deliver comprehensive toxicology assessments, utilizing specific dose administration techniques for comprehensive analysis.

Contact us for free quote to learn more about our toxicology CRO services.

    Preclinical Toxicology CRO Services

    We understand the importance of in vivo safety pharmacology assessments for evaluating the safety of drug products.

    Our preclinical toxicology research services form a crucial foundation for drug development processes. We evaluate a range of biological systems and uncover valuable insights into the toxicodynamics and toxicity profiles of new compounds.

    Our team employs cutting-edge techniques and methodologies to reveal potential risks and guide decision-making in pharmaceutical research. Check out the toxicology services that we offer at AniLocus:

    Toxicity Testing Services

    • Acute Toxicity Testing

      • Single-Dose Toxicity Study: Administer a high dose of the test substance to mice and observe for signs of acute toxicity over a short duration, typically 24-72 hours.

      Subacute Toxicity Testing:

      Subchronic Toxicity Testing:

      Chronic Toxicity Testing:

      • Chronic Toxicity and Carcinogenicity Study: Administer the substance over an extended period (usually 1-2 years) to assess chronic toxicity and carcinogenic potential.

      Reproductive Toxicity Testing:

      Developmental Toxicity Testing:

      Genotoxicity Testing:

      • Ames Test: Use bacterial strains to assess the substance’s mutagenic potential.
      • Micronucleus Test: Assess the substance’s ability to induce micronuclei in the mouse’s bone marrow cells.
      • Comet Assay: Examine DNA damage in mouse tissues following exposure to the substance.

      Dermal Toxicity Testing:

      • Dermal Irritation Study: Apply the substance to the skin to assess its irritant potential.
      • Dermal Sensitization Study: Evaluate the potential for the substance to induce skin sensitization.

      Inhalation Toxicity Testing:

      • Inhalation Exposure Study: Administer the substance through inhalation to assess respiratory toxicity.

      Neurotoxicity Testing:

      Organ-Specific Toxicity Testing:

      • Hepatotoxicity Study: Focus on assessing liver toxicity and damage.
      • Nephrotoxicity Study: Evaluate kidney toxicity and damage.
      • Cardiotoxicity Study: Investigate potential adverse effects on the cardiovascular system.

      Immunotoxicity Testing:

    Toxicokinetics ADME Studies

    Pharmacokinetics (PK) Studies:

    • Bioavailability Assessment: We can determine the extent and rate at which a substance is absorbed into the bloodstream following different routes of administration (e.g., oral, intravenous).
    • Plasma Concentration Profiling: We can measure the concentration of the test substance in blood plasma over time to understand its pharmacokinetic profile.

    Absorption Studies:

    • Permeability Assessments: We measure the permeability of the substance across biological membranes (e.g., intestinal, blood-brain barrier) using in vivo models.
    • GI Tract Absorption: We study the absorption of oral medications in the gastrointestinal (GI) tract to understand factors affecting bioavailability.

    Tissue Distribution Studies:

    • Tissue Sampling: We collect and analyze samples from various tissues to assess the distribution of the substance throughout the body.
    • Metabolite Identification: We identify and characterize metabolites in different tissues to understand where the substance is metabolized.

    Metabolism Studies:

    • In Vivo Metabolism: Evaluate in vivo metabolism by administering the substance to animal models and analyzing metabolites in biological samples.

    Excretion Studies:

    • Renal Excretion: We evaluate the excretion of the substance and its metabolites through the urine to assess the renal clearance.
    • Biliary Excretion: We assess the excretion of the substance into bile and its subsequent elimination through the feces.

    Stability Studies:

    • Stability Assessment: We determine the stability of the substance in various biological matrices (e.g., plasma, tissue homogenates) under different storage conditions.
    • Formulation Stability: We evaluate the stability of drug formulations to ensure shelf-life and administration reliability.

    Mass Balance Studies:

    • Total Recovery Studies: We conduct mass balance studies to account for the total recovery of the administered substance and its metabolites in various excreta (urine, feces).

    Pharmacokinetic Modeling and Simulation:

    • PK/PD Modeling: We perform pharmacokinetic/pharmacodynamic modeling to understand the relationship between drug exposure and effects, aiding in dose optimization.

    Analytical Services

    • Analytical Method Development: We create robust analytical methods for quantifying the substance and its metabolites in biological samples.
    • Bioanalysis: We can perform quantitative bioanalysis using validated analytical methods.

    Consultation and Regulatory Liaison:

    • Scientific Expertise: We offer expert guidance and consultation on ADME study design, execution, and interpretation.
    • Regulatory Interactions: We assist clients in interactions with regulatory agencies, addressing inquiries and ensuring compliance.

    Toxicity Data Analysis & Evaluation

    • Analyzing and evaluating toxicity data
    • We perform Data Interpretation of Complex findings
    • Robust data modeling techniques for toxicity biomarkers & toxicity endpoint assessment
    • Review our comprehensive list of data that can be collected from toxicity assays.
    Regulatory Compliance

    GLP

    Study Purpose

    Drug Safety

    Study Duration*

    Weeks to Months

    Animal Species

    Mouse, Rat

    Est. Research Budget*

    $50,000-$500,000

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