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Protocol: In Vivo Single-Dose Toxicity Study

In this protocol, we will focus on an in vivo single-dose toxicity study using mice as a the model for assessing toxicity of the test article. Research Objective To evaluate the acute toxicity of the test article and determine its potential adverse effects on mice after a single administration. Materials and Equipment Experimental Design Procedure […]

Protocol: Open Field Test (OFT)

The Open Field Test (OFT) is a versatile and widely employed behavioral assay in neuroscience research, offering multifaceted insights into rodent behavior beyond anxiety assessment. In addition to evaluating anxiety-related behaviors, the OFT can be tailored to explore various other dimensions of rodent behavior, including locomotion, exploratory tendencies, and even signs of depression-like behaviors. Researchers […]

Protocol: RNAscope® for Fixed Frozen Rodent Brain Sections

RNAscope® is a cutting-edge technique that enables the visualization of individual RNA molecules within individual cells and tissue. This assay, based on Advanced Cell Diagnostics patented technology, allows researchers to examine gene expression patterns and identify specific RNA targets in fixed cell and tissue samples. With its high sensitivity and specificity, RNAscope® holds immense potential […]

Protocol: Light Dark Box for Assessing Anxiety-Like Behaviors in Mice

Discover the highly effective Light Dark Box Protocol for evaluating anxiety-like behaviors in mice. Our comprehensive guide provides step-by-step instructions on implementing the protocol, its significance in behavioral studies, and the benefits it offers to researchers investigating anxiety and efficacy of anxiolytics. Here, we will share the key considerations, best practices, and potential applications of […]

Protocol: Barnes Maze for Mice and Rats

The Barnes Maze is a widely recognized and extensively used experimental procedure offers a systematic approach to assess cognitive abilities in rodents. We utilize this assay at our CRO for efficacy assessments of pharmaceuticas and devices for the following therapeutic areas: Purpose and Significance of the Barnes Maze Protocol The Barnes Maze Protocol serves as […]

Radial Arm Maze Protocol

Cognitive impairment, which includes memory loss, memory deficits, and learning disorders, can affect individuals of all ages. However, it is more commonly associated with aging. In older patients, diseases such as Alzheimer’s disease, Lewy body dementia, and vascular dementia are frequently linked to cognitive impairment. Nearly 80% of patients with Parkinson’s Disease develop dementia (Hely […]