Mouse Models of Locomotor Function | Centre Scientific
Studying Mouse Models of Locomotor Function | Centre Scientific

Studying Locomotor Activity in Animals

Locomotor activity can be studied in multiple animal models as a means to assess neuromuscular disease. Such diseases can be caused by neurodegeneration, pharmaceutical intervention, and much more. Activity is influenced by ability, sensory function, and motivation. It can be ambulatory (horizontal movements) or rearing (vertical movements).

In rodents, winged insects, or fish locomotor activity is quantified with the number of photoelectric beam interruptions placed within the home or activity cage. Multiple directions can be assessed and recorded to measure parameters within locomotion.

When offered a running wheel, rodents voluntarily and spontaneously use the wheel and can travel almost half a kilometer (approximately one-third of a mile) per hour during the night when they are most active.

In Zebrafish (Danio rerio), locomotor activity can be studied at multiple stages of life. Recent studies investigated the neural circuitry responsible for the initiation and sustainability of motion or neurotoxicity of psychostimulants or depressants.

The possibilities of what could be studied in animal models are endless and they provide background to our understanding of the development and the pathophysiology of neuromuscular disease.

At AniLocus, we provide mazes and apparatuses to assist in your investigation of locomotor activity and function.

Neuromuscular diseases

  • Alzheimer's disease (AD)
  • Amyotrophic lateral sclerosis (ALS)
  • Apraxia
  • Congenital myopathy
  • Hypertonia
  • Multiple sclerosis (MS)
  • Muscular dystrophy
  • Myasthenia gravis
  • Myositis
  • Peripheral neuropathy (diabetic)
  • Parkinson's
  • Spinal muscular atrophy
  • Spastic paraplegia

What We Offer at AniLocus

At AniLocus, you can utilize an open-field test for generalized assessment of locomotor activity.  With our camera-monitored activity chamber system you can monitor up to 36 different cages for locomotor analysis in your animal model. Our animal cage system can be monitored wireless or 24/7 on AC adapter.

Video footage provides an incredible amount of data for your animal models that can be analyzed with any software. To learn more about what we offer, please browse through our products.

  1. Ingebretson, J. J., & Masino, M. A. (2013). Quantification of locomotor activity in larval zebrafish: considerations for the design of high-throughput behavioral studies. Frontiers in neural circuits7, 109. doi:10.3389/fncir.2013.00109
  2. Manuel A. Giannoni-GuzmánArian AvalosJaime Marrero PerezEduardo J. Otero LoperenaMehmet KayımJose Alejandro MedinaSteve E. MasseyMeral KenceAykut KenceTugrul GirayJosé L. Agosto-Rivera
  3. Alexandros KyriakatosRiyadh MahmoodJessica AusbornChristian P. PorresAnsgar BüschgesAbdeljabbar El Manira. Initiation of Locomotion in Adult Zebrafish.
  4. Goh, J., & Ladiges, W. (2015). Voluntary Wheel Running in Mice. Current protocols in mouse biology5(4), 283–290. doi:10.1002/9780470942390.mo140295
  5. Neuromuscular Disorders. (2018, December 11). Retrieved December 15, 2019, from https://medlineplus.gov/neuromusculardisorders.html.