Novel Object Recognition Test (NORT) | Centre Scientific
Novel Object Recognition Test (NORT) | Centre Scientific

Studying Recognition Memory in Animal Models

The ability for animals to discern novel and familiar provides understanding of behavioral responses to novel and familiar objects. Novel objects can alter behavior and provoke stress, repetitive exposure to the novel object can assess these responses and determine when “novel” becomes “familiar”—if at all in the process of the experiment.

In humans, recognition memory is tested with visual comparison where an object and information may be mismatched in order to test proficiency at detecting the errors.

In rodents, recognition memory is assessed using novel object recognition tests and delayed matching/nonmatching to sample tests (DMST OR DNMST). These tests originated in 1970s and have progressed to the novel behavioral tests that exist today.

What is the significance of studying recognition memory?

Recognition memory can be impaired by congenital disorders, neurodegenerative disease, traumatic brain injury, and many other disorders.

Patients with lesions (damage) to the hippocampus have impaired recognition memory formation. Such deficits can be aseessed in primates and rodents to understand the pathophysiology of the damage to the hippocampus and the neural circuitry involved in memory formation.

What We Offer at AniLocus

At AniLocus, we offer multiple novel object recognition mazes and apparatuses that can be used with rodent, fish, or winged insect models to study recognition memory.

  • Two-trial novel object exploration
  • Three-trial novel object exploration
  • E-Maze
  • Open field test (OFT)
  1. Broadbent, N. J., Gaskin, S., Squire, L. R., & Clark, R. E. (2009). Object recognition memory and the rodent hippocampus. Learning & memory (Cold Spring Harbor, N.Y.)17(1), 5–11. doi:10.1101/lm.1650110
  2. Antunes, M., & Biala, G. (2012). The novel object recognition memory: neurobiology, test procedure, and its modifications. Cognitive processing13(2), 93–110. doi:10.1007/s10339-011-0430-z
  3. Albasser, M. M., Chapman, R. J., Amin, E., Iordanova, M. D., Vann, S. D., & Aggleton, J. P. (2010). New behavioral protocols to extend our knowledge of rodent object recognition memoryLearning & memory (Cold Spring Harbor, N.Y.)17(8), 407–419. doi:10.1101/lm.1879610
  4. Good, M. A., Hale, G., & Staal, V. (2007). Impaired “episodic-like” object memory in adult APPswe transgenic mice. Behavioral Neuroscience, 121(2), 443–448.
  5. Mishkin, M., & Delacour, J. (1975). An analysis of short-term visual memory in the monkey. Journal of Experimental Psychology: Animal Behavior Processes, 1(4), 326–334.