Bone & Joint Disease

Bone & Joint Disease

In Vivo Preclinical CRO Services for Bone & Joint Diseases and Orthopedic Disorders

Introducing Anilocus, your partner in in vivo research for orthopedic drug development. Our cutting-edge preclinical CRO services are specifically designed to address the challenges faced by Sponsors developing effective treatments for orthopedic disorders. With millions of patients suffering from chronic pain and discomfort, it’s crucial to find innovative solutions.

Our experienced team of orthopedic scientists specialize in the treatment of  conditions like osteoporosis, bone fractures, diabetic bone disease, and rare genetic bone disorders. By leveraging advanced techniques and creative approaches to complex studies, we provide comprehensive insights that accelerate the development of groundbreaking treatments. Choose Anilocus for unparalleled expertise in orthopedic research. Say goodbye to limitations and embrace new possibilities.

Collaborate with AniLocus to drive innovation and make significant strides in the field of bone disease research. 

Contact us today to discuss your research needs:

At AniLocus, we offer a comprehensive suite of services tailored to scientists and researchers seeking to outsource their preclinical studies in the field of bone disease.

Our Comprehensive Bone Disease and Orthopedic CRO Services

Explore the full spectrum of bone disease research and animal models for the following conditions, including:

  • Adams-Oliver Syndrome: Investigate the underlying mechanisms and potential therapeutic interventions for this rare genetic disorder characterized by limb and scalp anomalies.
  • Bone Infections: Study the pathogenesis of bone infections and evaluate novel antimicrobial agents for improved treatment outcomes.
  • Diabetic Cheiroarthropathy (Diabetic Hand Syndrome): Examine the impact of diabetes on hand joints and develop strategies to mitigate the progression of this complication.
  • Fibrous Dysplasia: Gain insights into the molecular basis of fibrous dysplasia and explore innovative treatment approaches.
  • Osteoarthritis: Investigate the mechanisms driving osteoarthritis progression and evaluate potential disease-modifying therapies.
  • Osteochondroma (Bone Tumor): Study the biology of osteochondroma and explore targeted therapeutic options for patients.
  • Osteogenesis Imperfecta: Advance our understanding of this genetic disorder characterized by brittle bones and develop potential interventions.
  • Osteomyelitis: Investigate bone infection mechanisms, antibiotic efficacy, and novel treatment strategies.
  • Osteonecrosis: Explore the underlying causes of bone tissue death and develop interventions to preserve joint function.
  • Osteopetrosis: Investigate the genetics and pathophysiology of this rare condition and explore potential therapies.
  • Osteoporosis: Evaluate bone density and strength and develop innovative approaches to prevent and treat osteoporosis.
  • Paget’s Disease of Bone: Study the cellular and molecular basis of Paget’s disease and identify therapeutic targets.
  • Scoliosis: Investigate the etiology of scoliosis and explore potential interventions to correct spinal deformities.

Why Choose AniLocus for Your Bone Disease Research?

  • Expertise: Our team comprises experienced scientists and researchers with a deep understanding of bone diseases and preclinical research.
  • Customized Solutions: We tailor our services to meet your specific research goals, ensuring comprehensive and targeted investigations.
  • Ethical and Regulatory Compliance: We prioritize ethical treatment of animals in research and adhere to all regulatory guidelines for preclinical studies.

Frequently Asked Questions

From Sponsors about in vivo assessments of therapeutics for bone diseases: 

When selecting an animal model for an in vivo bone disease study, it is important to consider the similarity of the animal’s anatomy and physiology to humans. Different factors such as genetic similarity, size, anatomical characteristics, and ease of handling should be taken into account when making a selection.

For example, if the experiment requires that the animals be easily manipulated, a smaller animal like a mouse may be the best choice. Additionally, some species may be better suited to certain experiments than others and at times a specific species such as rabbit, rat, canine, or non-human primate may be necessary but more expensive solutions to complete IND-enabling or NDA-enabling studies.

The experimental timeline for acute and long-term in vivo studies of bone disease and orthopedic disorders in mice can vary greatly depending on the specific study.

Acute studies typically last anywhere from 1-21 days, while long-term studies usually last for several weeks to several months. It is important to note that the timeline for the study may be affected by the type of bone disease or orthopedic disorder being studied as well as the type of mouse used.

For example, an acute study involving a strain of mice prone to rapid aging or with a predisposition to certain bone diseases may require a longer timeline than an acute study of a healthy mouse.

Drug modalities are different types of therapeutic agents. Each drug is a customizable tool designed for therapeutic intervention. The question is…does your product work and is it safe?

At AniLocus, we conduct relevant preclinical studies to assess any drug modality:

  • Antibodies (nanobodies, monoclonal)
  • Gene therapy (CRISPR, TALEN)
  • Viral therapy (adenovirus-AAV, lentivirus)
  • Oligo- and polypeptides (e.g., stapled and modified peptides)
  • Oligo- and polynucleotides (e.g., siRNAs, mRNAs, aptamers)
  • Polyglycosides
  • Macrocyclic molecules
  • Drug conjugates (e.g., antibody–drug conjugates, drug–drug conjugates, fluorescence-labeled drugs)
  • Targeted protein degraders (e.g., proteolysis-targeting chimeras (PROTACs) and molecular glues) that induce a chemical knockdown of proteins
  • Cellular therapies (stem cells, allogenic, autologous)

Using animal and human cells and tissue we can perform multiple interrogative assays depending on therapeutic area and sample type:

  • DNA: Extraction, PCR, ddPCR, qPCR, sequencing, genotyping
  • RNA: Gene expression profiling, RT-PCR, miRNA, Next-generation sequencing (Nanostring, Illumina), spatial transcriptomics, In situ hybridization (ISH), Multiplex ISH
  • Protein: Immunoassays (ELISA, EIA, Luminex), proteomics, ligand binding assays, protein expression, immunohistochemistry (IHC), immunocytochemistry (ICC), and  immunofluorescence (IF)
  • And more!

The estimated cost to run in vivo laboratory animal studies will depend on various factors, such as the type of study, the type of animal used, and the duration of the study. Generally speaking, these types of studies can range in cost from a few thousand dollars to hundreds of thousands of dollars depending on the specifics of the study.